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binding of trastuzumab to her2 inhibits ligand-independent her2 signalling and prevents the proteolytic cleavage of its extracellular domain, an activation mechanism of her2.
trastuzumabi seondumine her2-ga inhibeerib ligandist sõltumatuid her2 signaaliradasid ja takistab tema ekstratsellulaarse domeeni, mis on her2 aktivatsioonimehhanism, proteolüütilist lõhustamist.
trastuzumab emtansine, like trastuzumab, binds to domain iv of the her2 extracellular domain (ecd), as well as to fcγ receptors and complement c1q.
trastuzumabemtansiin seondub sarnaselt trastuzumabiga her2 ekstratsellulaarse domeeni (ecd) domeeniga iv, samuti fcγ retseptorite ja komplement c1q-ga.
circulating shed antigen detectable concentrations of the circulating extracellular domain of the her2 receptor (shed antigen) are found in the serum of some patients with her2 overexpressing breast cancers.
tsirkuleeriv antigeen her2 ekstratsellulaarse domeeni (tsirkuleeriv antigeen) kontsentratsioonid on määratavad mõnede patsientide seerumist, kelle rinnanäärme kartsinoomil esineb her2 üleekspressioon.
aflibercept is a recombinant fusion protein consisting of portions of human vegf receptor 1 and 2 extracellular domains fused to the fc portion of human igg1.
aflibertsept on rekombinantne sulandvalk, mis koosneb inimese vegf-i retseptorite 1 ja 2 ekstratsellulaarsetest domeenidest, mis on liidetud inimese igg1 fc-osaga.
etanercept is a dimer of a chimeric protein genetically engineered by fusing the extracellular ligand binding domain of human tumour necrosis factor receptor-2 (tnfr2/p75) to the fc domain of human igg1.
etanertsept on kimäärse proteiini dimeer, mis on saadud geneetiliselt, liites ekstratsellulaarset ligandi siduva inimese tuumornekroosifaktori retseptor-2 (tnfr2/p75) domeeni inimese igg1 fc-domeeniga.
aflibercept, also known as vegf trap in the scientific literature, is a recombinant fusion protein consisting of vegf-binding portions from the extracellular domains of human vegf receptors 1 and 2 fused to the fc portion of the human igg1.
aflibertsept, mida teaduskirjanduses tuntakse ka nime all vegf trap, on rekombinantne fusioonvalk, mis koosneb inimese vegf retseptorite 1 ja 2 rakuväliste domeenide vegf –iga seonduvatest osadest, liidetult inimese igg1 fc-osaga.