Imparare a tradurre dagli esempi di traduzione forniti da contributi umani.
Da traduttori professionisti, imprese, pagine web e archivi di traduzione disponibili gratuitamente al pubblico.
(3) cfr. appendice alla parte i della sua "ethica more geometrico demonstrata" più conosciuta come " etica ".
[iii] cfr. appendix to part i of ethica more geometrico demonstrata (better known as etica).
Ultimo aggiornamento 2018-02-13
Frequenza di utilizzo: 1
Qualità:
Attenzione: contiene formattazione HTML nascosta
high-throughput screening (hts) previously identified benzimidazole 1 (jmn3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. in pursuit of a lead compound from this series for development, we sought to increase both the potency and the aqueous solubility of 1. lead optimization has achieved compounds with potent antiviral activity against a panel of myxovirus family members (ec50 values in the low nanomolar range) and much improved aqueous solubilities relative to that of 1. additionally, we have devised a robust synthetic strategy for preparing 1 and congeners in an enantio-enriched fashion, which has allowed us to demonstrate that the (s)-enantiomers are generally 7- to 110-fold more potent than the corresponding (r)-isomers.
academic publishing