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it is a humanized monoclonal antibody that binds specifically to the α4β7 integrin, which is preferentially expressed on gut homing t helper lymphocytes.
huwa antikorp monoklonali umanizzat li jeħel speċifikament mal integrin α4β7, li huwa preżenti b’mod preferenzjali fuq limfoċiti t helper li jfittxu l-musrana.
tacrolimus suppresses t-cell activation and t-helper-cell dependent b-cell proliferation, as well as the formation of lymphokines (such as interleukins-2, -3, and γ-interferon) and the expression of the interleukin-2 receptor.
tacrolimus jissopprimi l-attivazzjoni tat-t-cell u t-tixrid tal-b-cell li hu dipendenti fuq it-t-helper-cell, kif ukoll il-formazzjoni ta’ limfokini (bħal l-interlewkini 2, -3, u l- γ- interferon) u l-espressjoni tar-reċettur interlewkin-2.