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meningococcal group y oligosaccharide 5 micrograms conjugated to corynebacterium diphtheriae crm197 protein 5.6 to 10.0 micrograms
oligosaccharide ta’ grupp meningokokkali y 5 mikrogrammi konjugat għal proteina corynebacterium diphtheriae crm197 5.6 sa 10.0 mikrogrammi
meningococcal group a oligosaccharide 10 micrograms conjugated to corynebacterium diphtheriae crm197 protein 16.7 to 33.3 micrograms
oligosaccharide ta’ grupp meningokokkali a 10 mikrogrammi konjugat għal proteina corynebacterium diphtheriae crm197 16.7 sa 33.3 mikrogrammi
there are several applications, such as ecklonia cava phlorotannins, xylo-oligosaccharide and spray dried extract of terminalia ferdinandiana exell, that are currently being assessed by the member states.
bħalissa hemm bosta applikazzjonijiet li qed jivvalutaw l-istati membri, fosthom tal-florotannini ecklonia cava, iż-żilo-oligosakkarid u l-estratt imnixxef bl-isprejj tat-terminalia ferdinandiana exell.
idursulfase is secreted as a 525 amino acid glycoprotein and contains 8 n-linked glycosylation sites that are occupied by complex, hybrid, and high-mannose type oligosaccharide chains.
idursulfase tiġi rilaxxata bħala 525 amino acid glycoprotein u fiha 8 siti ta’ n-linked glycosylation li huma okkupati minn ktajjen oligosaccharide tat-tip ibridi u b’ħafna mannose kumplessi.
mannose-6-phosphate (m6p) residues on the oligosaccharide chains allow specific binding of the enzyme to the m6p receptors on the cell surface, leading to cellular internalization of the enzyme, targeting to intracellular lysosomes and subsequent catabolism of accumulated gag.
residwi ta’ mannose-6-phosphate (m6p) fuq il-ktajjen ta’ oligosaccharide iħallu rbit speċifiku ta’ l-enzima ma’ riċetturi m6p fuq il-wiċċ taċ-ċellola, li jwassal għal internalizzazzjoni ċellolari ta’ l-enzima, immirata għal liżożomi ċellolari u kataboliżmu sussegwenti ta’ gag akkumulati.
