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at the request of sanitary maintenance of hardness salts in tap water should not exceed 7 meq/liter.
По требованию санитарных норм содержание солей жесткости в водопроводной воде не должно превышать 7 мг-экв/л.
*cardiovascular dysfunction (after fluid resuscitation with at least 40 ml/kg of crystalloid)**hypotension with blood pressure 5 meq/l***lactic acidosis: serum lactate 2 times the upper limit of normal***oliguria (urine output )***prolonged capillary refill > 5 seconds***core to peripheral temperature difference*respiratory dysfunction (in the absence of cyanotic heart disease or known chronic lung disease)**the ratio of the arterial partial-pressure of oxygen to the fraction of oxygen in the gases inspired (pao2/fio2) 65 torr (20 mmhg) over baseline paco2 (evidence of hypercapnic respiratory failure), or**supplemental oxygen requirement of greater than fio2 0.5 to maintain oxygen saturation ≥ 92%*neurologic dysfunction**glasgow coma score (gcs) ≤ 11, or**altered mental status with drop in gcs of 3 or more points in a patient with developmental delay/intellectual disability*hematologic dysfunction**platelet count or 50% drop from maximum in chronically thrombocytopenic patients, or**international normalized ratio (inr) > 2**disseminated intravascular coagulation*kidney dysfunction**serum creatinine ≥ 2 times the upper limit of normal for age or 2-fold increase in baseline creatinine in patients with chronic kidney disease*liver dysfunction (only applicable to infants > 1 month)**total serum bilirubin ≥ 4 mg/dl, or**alanine aminotransferase (alt) ≥ 2 times the upper limit of normalconsensus definitions, however, continue to evolve, with the latest expanding the list of signs and symptoms of sepsis to reflect clinical bedside experience.
* cardiovascular dysfunction (after fluid resuscitation with at least 40 ml/kg of crystalloid)** hypotension with blood pressure 5 meq/l*** lactic acidosis: serum lactate 2 times the upper limit of normal*** oliguria (urine output 5 seconds*** core to peripheral temperature difference > 3 °c* respiratory dysfunction (in the absence of cyanotic heart disease or known chronic lung disease)** the ratio of the arterial partial-pressure of oxygen to the fraction of oxygen in the gases inspired (pao2/fio2) 65 torr (20 mmhg) over baseline paco2 (evidence of hypercapnic respiratory failure), or** supplemental oxygen requirement of greater than fio2 0.5 to maintain oxygen saturation ≥ 92 %* neurologic dysfunction** glasgow coma score (gcs) ≤ 11, or** altered mental status with drop in gcs of 3 or more points in a patient with developmental delay/mental retardation* hematologic dysfunction** platelet count 2* renal dysfunction** serum creatinine ≥ 2 times the upper limit of normal for age or 2-fold increase in baseline creatinine in patients with chronic kidney disease* hepatic dysfunction (only applicable to infants > 1 month)** total serum bilirubin ≥ 4 mg/dl, or** alanine aminotransferase (alt) ≥ 2 times the upper limit of normal=== neonatal sepsis ===in common clinical usage, sepsis specifically refers to the presence of a serious bacterial infection(sbi) (such as meningitis, pneumonia, pyelonephritis, or gastroenteritis) in the setting of fever.