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at high doses (≥450 mg/kg/day) rats exhibited a prolongation of oestrous cycle and a high incidence of irregular cycles.
pri visokih odmerkih (≥ 450 mg/kg/dan) se je pri podganah ciklus estrusa podaljšal, nepravilnih ciklov pa je bilo več.
females should be left with the males for at least the duration of one oestrous cycle or until mating has occurred as determined by the presence of sperm in the vagina or by the presence of a vaginal plug.
samice je treba pustiti s samci za čas najmanj enega pojatvenega cikla ali dokler se ne zgodi parjenje, kar se ugotovi ob prisotnosti semenčec v vagini ali ob prisotnosti vaginalnega zamaška.
oestrous cycles and fertility were adversely affected in all bazedoxifene- treated female groups.
v vseh skupinah samic, ki so prejemale bazedoksifen, so opazili neželene učinke na estrusne cikle in plodnost.
in animal studies, pramipexole affected oestrous cycles and reduced female fertility as expected for a dopamine agonist.
v študijah na živalih je pramipeksol vplival na paritvene cikluse in zmanjšal plodnost samic, kar je pričakovani učinek agonista dopamina.
during the fertility studies, a reduction in the number of corpora lutea and prolonged oestrous cycle were observed at dose levels that were associated with decreased food intake and body weight gain in maternal animals; however, no effects on indices of fertility and conception or embryonic development were observed.
med raziskavami plodnosti so opazili zmanjšano število rumenih telesc in podaljšan estrusni cikel pri ravneh odmerka, povezanih z zmanjšanim vnosom hrane in zmanjšanim pridobivanjem telesne mase pri materi; kljub temu pa niso opazili nobenih učinkov na kazalce plodnosti in spočetja ali embrionalni razvoj.
reproductive and developmental toxicity studies showed that oestrous cycles were prolonged in rats treated with high doses of tasimelteon, with no effect on mating performance or male fertility, and only a marginal effect on female fertility.
Študije o vplivu na sposobnost razmnoževanja in razvoja so pokazale, da so se pri podganah, zdravljenih z velikimi odmerki tasimelteona, podaljšali estrusni ciklusi, niso pa pokazale vpliva na uspešnost parjenja ali plodnost samcev in samo zanemarljiv vpliv na plodnost samic.
female rats receiving duloxetine before and during mating and early pregnancy had a decrease in maternal food consumption and body weight, oestrous cycle disruption, decreased live birth indices and progeny survival, and progeny growth retardation at systemic exposure levels estimated to be at the most at maximum clinical exposure (auc).
podganje samice, ki so prejemale duloksetin pred in med parjenjem ter zgodnjo brejostjo, so kazale zmanjšano porabo hrane in znižanje telesne mase pri materah, motnje estrus ciklusa, zmanjšano število živorojenih in slabše preživetje potomcev ter zastoj rasti potomcev pri sistemskih izpostavitvah, ocenjenih kot največ maksimalna klinična izpostavitev (auc).
reductions in oestrous cycles were observed at 50 mg/kg/day, a dose associated with maternal toxicity (body weight loss and reduced food consumption).
pri 50 mg/kg/dan so opazili zmanjšanje estrusnih ciklusov; ta odmerek je bil povezan s toksičnostjo za samice-matere (izguba telesne mase in manjše uživanje hrane).
