Sie suchten nach: poliproteinelor (Rumänisch - Englisch)

nelfinavirul se leagă reversibil de situsul activ al proteazei hiv şi previne clivajul poliproteinelor rezultând formarea de particule virale imature neinfecţioase.
nelfinavir reversibly binds to the active site of hiv protease and prevents cleavage of the polyproteins resulting in the formation of immature non-infectious viral particles.

inhibă selectiv scindarea poliproteinelor hiv codate gag-pol în celulele infectate de virus, prevenind astfel formarea de particule virale mature infectante.
it selectively inhibits the cleavage of hiv encoded gag-pol polyproteins in virus infected cells, thereby preventing the formation of mature infectious virus particles.

mecanism de acţiune: proteaza hiv este o enzimă virală esenţială necesară pentru clivajul specific al genelor virale gag şi poliproteinelor gag-pol.
mechanism of action: the hiv protease is an essential viral enzyme required for the specific cleavage of viral gag and gag-pol polyproteins.

amprenavirul se fixează la situsul activ al proteazei hiv-1 şi astfel previne dezvoltarea precursorilor poliproteinelor gag şi gag- pol, ducând la formarea de particule virale neinfecţioase imature.
amprenavir binds to the active site of hiv-1 protease and thereby prevents the processing of viral gag and gag-pol polyprotein precursors, resulting in the formation of immature non-infectious viral particles.

clivajul acestor poliproteine virale este esenţial pentru maturarea formei infecţioase a virusului.
the cleavage of these viral polyproteins is essential for the maturation of infectious virus.