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nakon dvogodišnje primjene abakavira primijećena je blaga degeneracija miokarda u miševa i štakora.
mild myocardial degeneration in the heart of mice and rats was observed following administration of abacavir for two years.
degeneracija sjemenskog epitela bila je povezana s palonozetronom nakon mjesec dana ispitivanja toksičnosti ponovljenih peroralnih doze u štakora.
degeneration of seminiferous epithelium was associated with palonosetron following a one month oral repeat dose toxicity study in rats.
degeneracija mrežnice nije uočena u majmuna usprkos većoj sistemskoj izloženosti nego u glodavaca ili u bolesnika na maksimalnoj ljudskoj dozi.
no retinal degeneration was noted in monkeys despite higher systemic exposure than in rodents or in patients at the maximum human dose.
degeneracija retine nije uočena tijekom rutinskih histopatoloških pregleda očiju u drugim toksikološkim studijama, neovisno o životinjskim vrstama.
retinal degeneration was not observed during the routine histopathological evaluation of the eyes in any of the toxicology studies in any species used.
sprječava pojavu gastritisa , čira na želucu i dvanaestercu . Štiti jetru od masnih degeneracija , povoljno djeluje na izlučivanje žuči .
it prevents gastritis , gastric and duodenal ulcers , fatty degenerations of the liver and helps flush out the gallbladder .
degeneracija mrežnice uočena je u glodavaca nakon ponovljenih doziranja safinamida što je rezultiralo sistemskom izloženošću ispod očekivane sistemske izloženosti u bolesnika koji su primili maksimalnu terapijsku dozu.
retinal degeneration was observed in rodents after repeated safinamide dosing resulting in systemic exposure below the anticipated systemic exposure in patients given the maximal therapeutic dose.
histološki je, osim toga, opažena neznatna ili vrlo mala degeneracija skeletnih mišića pri dozama koje su dovele do razina sistemske izloženosti oko 23 puta veće od razine izloženosti u ljudi.
in addition, very slight to slight skeletal muscle degeneration was also observed histologically at doses resulting in systemic exposure levels of approximately 23 times the human exposure level.
blaga degeneracija bubrežnih kanalića uočena je u miševa u kojih je izloženost bila najmanje dvostruko veća od one preporučene u ljudi; ni u štakora ni u pasa nije bilo učinaka na bubrege.
mild renal tubular degeneration was confined to mice exposed with at least twice the recommended human exposure; the kidney was unaffected in rats and dogs.
u ispitivanjima toksičnosti ponovljenih doza na štakorima, epitelna degeneracija sjemenih kanalića i segmentna hipoplazija testisa zabilježena je kod 10 puta veće izloženosti od predviđene izloženosti u ljudi na temelju auc-a.
in rat repeated dose toxicity studies, seminiferous epithelial degeneration and segmental hypoplasia of the testes was seen at 10-fold of predicted human exposure based on auc.
u ispitivanju u trajanju od 3 mjeseca nakon primjene doze koja je bila 2,8 puta veća od najveće preporučene za ljude izražene u mg/m2, u albino štakora transmisijskim mikroskopom uočena je degeneracija retine.
retinal degeneration was observed by transmission microscopy at a dose equivalent to 2.8 times the maximum recommended human dose on a mg/m² basis in a 3-month study in albino rats.
međutim, u ispitivanjima toksičnosti ponovljenih doza opažena je degeneracija seminalnih vezikula i atrofija sjemenovodnih kanalića u testisima štakora te degeneracija testisa (minimalna nekroza pojedinačnih epitelnih stanica u epididimisu) u pasa.
however, in repeated-dose toxicity studies, degeneration of seminal vesicle and seminiferous tubule atrophy in the testis were observed in rats, and testicular degeneration (minimal epithelial single cell necrosis in epididymis), was observed in dogs.
u ispitivanjima toksičnosti ponovljenih doza, zamijećena je povećana incidencija anestrusa, degeneracija žutog tijela u jajnicima i stanjivanje epitela maternice i vagine u štakora izloženih osimertinibu tijekom razdoblja ≥1 mjesec pri klinički relevantnim koncentracijama u plazmi.
in repeat dose toxicity studies, an increased incidence of anoestrus, corpora lutea degeneration in the ovaries and epithelial thinning in the uterus and vagina were seen in rats exposed to osimertinib for ≥1 month at clinically relevant plasma concentrations.
