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u ispitivanju sa slabim metabolizatorima cyp2d6 nisu pronađeni dokazi klinički značajnog učinka genetskog polimorfizma cyp2d6 na sistemsku izloženost umeklidinijevu bromidu.
a study in cyp2d6 poor metabolisers showed no evidence of a clinically significant effect of cyp2d6 genetic polymorphism on systemic exposure to umeclidinium bromide.
Last Update: 2017-04-26
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u osoba s teškim oštećenjem bubrežne funkcije (klirens kreatinina < 30 ml/min) nisu pronađeni dokazi povećane sistemske izloženosti umeklidinijevu bromidu (cmax i auc) niti dokazi promijenjenog vezanja za proteine u ispitanika s teškim oštećenjem bubrežne funkcije u odnosu na zdrave dobrovoljce.
subjects with severe renal impairment (creatinine clearance <30ml/min) showed no evidence of an increase in systemic exposure to umeclidinium bromide (cmax and auc), and no evidence of altered protein binding between subjects with severe renal impairment and healthy volunteers.
Last Update: 2017-04-26
Usage Frequency: 1
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