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buprenorphin metaboliseres ved 14-n-dealkylering og glukuronidkonjugering af modersubstansen og de dealkylerede metabolitter.
buprenorphine is metabolised by 14-n-dealkylation and glucuroconjugation of the parent molecule and the dealkylated metabolite.
aripiprazol metaboliseres hovedsageligt i leveren via tre biotransformationsveje: dehydrogenering, hydroxylering og n-dealkylering.
aripiprazole is extensively metabolised by the liver primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and n-dealkylation.
aripiprazol metaboliseres i stor udstrækning i leveren via tre biotransformationsveje: dehydrogenering, hydroxylering og n-dealkylering.
aripiprazole is extensively metabolised by the liver primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and n-dealkylation.
buprenorphin metaboliseres ved 14- n- dealkylering og glukuronid- konjugering af modermolekylet og den dealkylerede metabolit.
buprenorphine is metabolised by 14-n-dealkylation and glucuroconjugation of the parent molecule and the dealkylated metabolite.
mirabegron metaboliseres via flere pathways, som involverer dealkylering, oxidation, (direkte) glucuronidering og amidhydrolyse.
mirabegron is metabolized via multiple pathways involving dealkylation, oxidation, (direct) glucuronidation, and amide hydrolysis.
de vigtigste påviste metaboliseringsveje er oxidation og nedbrydning af imidazol- og piperazinringene, oxidativ o-dealkylering og aromatisk hydroxylering.
the major identified metabolic pathways are oxidation and degradation of the imidazole and piperazine rings, oxidative o-dealkylation and aromatic hydroxylation.
baseret på in vitro-forsøg er cyp3a4 og cyp2d6 ansvarlige for dehydrogenering og hydroxylering af aripiprazol, og n-dealkylering katalyseres ved cyp3a4.
based on in vitro studies, cyp3a4 and cyp2d6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and n-dealkylation is catalysed by cyp3a4.
de tre vigtigste metaboliseringsveje er følgende: monohydroxylering i dihydrobenzfuranringen; åbning af dihydrobenzfuranringen og; n- dealkylering af nitrogen i pyrrolidin.
the three main metabolic routes are as follows: monohydroxylation in the dihydrobenzofuran ring; dihydrobenzofuran ring opening and n-dealkylation of the pyrrolidine nitrogen.
der er identificeret fire metaboliske processer in vivo, hvoraf ingen udgjorde mere end 10 % af dosis: nemlig dealkylering, hydroxylering, dehydrogenering og benzisoxazolspaltning.
four metabolic pathways have been identified in vivo, none of which accounted for more than 10% of the dose: dealkylation, hydroxylation, dehydrogenation, and benzisoxazole scission.
ifølge in vitro-studier er cyp3a4- og cyp2d6- enzymer ansvarlige for dehydrogenering og hydroxylering af aripiprazol, og n-dealkylering katalyseres ved cyp3a4.
based on in vitro studies, cyp3a4 and cyp2d6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and n-dealkylation is catalysed by cyp3a4.
kliniske data bekræfter, at cyp3a4 er årsagen til n-dealkyleringen af buprenorphin.
clinical data confirm that cyp3a4 is responsible for the n-10 dealkylation of buprenorphine.