Results for simvastatinsyre translation from Danish to English

simvastatinsyre:
simvastatin acid:

76% (63 til 79) simvastatinsyre:
76% (63 to 79) simvastatin acid:

69% og 76%, for simvastatinsyre med hhv.
no dosage adjustment is necessary for efavirenz.

cmax: ↓ 76% (↓ 63 til ↓ 79) simvastatinsyre:
cmax: 0 76% (0 63 to 0 79)

telithromycin forårsagede en 11 gang forøgelse i optagelsen af simvastatinsyre.
telithromycin caused an 11-fold increase in exposure to simvastatin acid.

den øgede eksponering for simvastatin og simvastatinsyre anses ikke for klinisk relevant.
the increases in simvastatin and simvastatin acid exposures are not considered clinically relevant.

1.000 mg to gange dagligt fik plasmakoncentrationen af simvastatinlacton og simvastatinsyre til at stige med faktor 2.
1000 mg twice daily increased plasma concentrations of simvastatin lactone, simvastatin acidby about 2-fold.

hos normale frivillige faldt eksponeringen for simvastatinsyre i plasma med 93 % med samtidig administration af rifampicin.
in normal volunteers, the plasma exposure to simvastatin acid was decreased by 93% with concomitant administration of rifampicin.

1.000 mg to gange dagligt fik plasmakoncentrationen af simvastatinlacton og simvastatinsyre til at stige med cirka en faktor 2.
1000 mg twice daily increased plasma concentrations of simvastatin lactone, simvastatin acid by about 2 fold.

dronedaron (400 mg to gange daglig) øgede plasmakoncentrationen af simvastatin og simvastatinsyre henholdsvis 4 og 2 gange.
dronedarone (400 mg twice daily) increased simvastatin and simvastatin acid exposure by 4-fold and 2-fold respectively.

indtag af 240 ml grapefrugtjuice om morgenen og simvastatin om aftenen resulterede også i en 1,9 gange stor øgning for eksponeringen af simvastatinsyre i plasma.
intake of 240 ml of grapefruit juice in the morning and simvastatin in the evening also resulted in a 1.9-fold increase in plasma exposure to simvastatin acid.

samtidig indtagelse af store mængder (over 1 liter dagligt) grapefrugtjuice og simvastatin resulterede i en 7 gange forøgelse i optagelsen af simvastatinsyre.
concomitant intake of large quantities (over 1 litre daily) of grapefruit juice and simvastatin resulted in a 7-fold increase in exposure to simvastatin acid.

i et farmakokinetisk studie resulterede samtidig indgivelse af verapamil i en 2, 3 gang forøgelse i optagelse af simvastatinsyre, delvist, formodentlig, på grund af cyp3a4 hæmningen.
in a pharmacokinetic study, concomitant administration with verapamil resulted in a 2.3-fold increase in exposure of simvastatin acid, presumably due, in part, to inhibition of cyp3a4.

statiner når simvastatin blev administreret samtidig med ketek, steg simvastatin cmax 5, 3 gange og simvastatin auc steg 8, 9 gange, simvastatinsyre cmax steg 15 gange og simvastatinsyre auc steg 11 gange.
statins when simvastatin was coadministered with ketek, there was a 5.3 fold increase in simvastatin cmax, an 8.9 fold increase in simvastatin auc, a 15-fold increase in simvastatin acid cmax and an 11-fold increase in simvastatine acid auc.

gemfibrozil gemfibrozil forøger auc af simvastatinsyre 1, 9 gange muligvis på grund af hæmning af glukoroniseringen (se pkt.4. 2 og 4. 4) .
gemfibrozil gemfibrozil increases the auc of simvastatin acid by 1.9-fold, possibly due to inhibition of the glucuronidation pathway (see sections 4.2 and 4.4) .

4. 4) .i en farmakokinetisk undersøgelse forårsagede samtidig indgivelse af diltiazem en 2, 7 gang forøgelse i optagelsen af simvastatinsyre, formodentlig på grund af cyp3a4 hæmningen.derfor bør simvastatin
in a pharmacokinetic study, concomitant administration of diltiazem caused a 2.7-fold increase in exposure of simvastatin acid, presumably due to inhibition of cyp3a4.

simvastatin:co-administration af efavirenz (600 mg peroralt en gang dagligt) sammen med simvastatin (40 mg peroralt en gang dagligt) hos ikke-inficerede frivillige nedsatte steady-state auc og cmax for simvastatin med hhv.69% og 76%, for simvastatinsyre med hhv.58% og 51%, for total aktiv hmg-coa reduktasehæmmere med hhv. 60% og 62% og for total hmg-coa reduktasehæmmere med hhv.60% og 70%, sammenlignet med simvastatin, der er administreret alene.
simvastatin: co-administration of efavirenz (600 mg orally once daily) with simvastatin (40 mg orally once daily) in uninfected volunteers decreased the steady-state auc and cmax of simvastatin by 69% and 76%, respectively, of simvastatin acid by 58% and 51%, respectively, of total active hmg-coa reductase inhibitors by 60% and 62%, respectively, and of total hmg-coa reductase inhibitors by 60% and 70%, respectively, compared to simvastatin administered alone.