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det antages almindeligvis, at der for denne type carcinogen ikke eksisterer en tærskeldosis, hvorunder der ikke finder tumordannelse sted.
for this type of carcinogen, it is generally felt that there is no threshold dose below which no tumour formation would occur.
for ikke-genotoksiske kræftfremkaldende stoffers vedkommende identificere den største dosis, der ikke giver skadelige virkninger (tærskeldosis).
for non-genotoxic carcinogens, to identify the maximum dose eliciting no adverse effect (threshold dose).
den letale tærskeldosis, tidsforløb for respons og helbredelse samt ld10 og ld20 skal oplyses tillige med nul-effekt-niveauet (noel) og makropatologiske fund.
the lethal threshold dose, time courses of response and recovery, the ld10 and ld20 shall be reported together with the no observed effect level (noel) and gross pathological findings.
det gennemsnitlige behov for kvinder fastlægges således som 1,1 mg/d, med en referenccdosis for befolkningen på 1,3 mg/d. den laveste tærskeldosis reduceres ikke til under 0,6 mg/d, eftersom det ikke er dokumenteret, at dette ville være uden sundhedsrisiko for kvinder.
in subjects maintained on graded intakes of riboflavin from 0.55-3.55 mg/d, there is a clear inflection in the relationship between intake and excretion, with a considerable increase in the excretion of the vitamin as intake is increased from 1.1 to 1.6 mg/d.