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virkningsmekanismen inkluderer en binding af faktor viia til eksponeret vævsfaktor.
the mechanism of action includes the binding of factor viia to exposed tissue factor.
Last Update: 2017-04-26
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dette medfører omdannelse af protrombin til store mængder trombin uafhængigt af vævsfaktor.
this results in the conversion of prothrombin into large amounts of thrombin independently of tissue factor.
Last Update: 2017-04-26
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farmakologiske doser af novoseven aktiverer faktor x direkte på overfladen af aktiverede blodplader på selve læsionsstedet uafhængigt af vævsfaktor.
pharmacological doses of novoseven activate factor x directly on the surface of activated platelets, localized to the site of injury, independently of tissue factor.
Last Update: 2017-04-26
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faktor ix aktiveres af faktor vii/vævsfaktor kompleks i "extrinsic pathway" så vel som faktor xia i "intrinsic coagulation pathway".
factor ix is activated by factor vii/tissue factor complex in the extrinsic pathway as well as factor xia in the intrinsic coagulation pathway.
Last Update: 2017-04-26
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i patologiske tilstande, hvor vævsfaktorer kan forventes at forekomme i højere grad end normalt, kan der være potentiel risiko for udvikling af tromboseepisoder eller induktion af dissemineret intravaskulær koagulation (dic) i forbindelse med behandling med novoseven.
in pathological conditions in which tissue factor may be expressed more extensively than considered normal, there may be a potential risk of development of thrombotic events or induction of disseminated intravascular coagulation (dic) in association with novoseven treatment.
Last Update: 2017-04-26
Usage Frequency: 9
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