Results for doelorgaaneffecten translation from Dutch to English

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doelorgaaneffecten

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doelorgaaneffecten vertoonden partieel tot compleet herstel.

English

target organ effects showed partial to complete recovery.

Last Update: 2017-04-26
Usage Frequency: 1
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Dutch

preklinische onderzoeken uitgevoerd bij ratten, honden en apen toonden doelorgaaneffecten aan in maagdarmkanaal, nier, bot en een afname van de serumfosfaatconcentratie.

English

preclinical studies conducted in rats, dogs and monkeys revealed target organ effects in gastrointestinal tract, kidney, bone and a decrease in serum phosphate concentration.

Last Update: 2012-04-11
Usage Frequency: 2
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Dutch

preklinisch onderzoek van tenofovirdisoproxilfumaraat uitgevoerd bij ratten, honden en apen toonde doelorgaaneffecten aan in maagdarmkanaal, nier, bot en een afname van de serumfosfaatconcentratie.

English

preclinical studies of tenofovir disoproxil fumarate conducted in rats, dogs and monkeys revealed target organ effects in gastrointestinal tract, kidney, bone and a decrease in serum phosphate concentration.

Last Update: 2012-04-11
Usage Frequency: 2
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Dutch

bij onderzoeken naar toxiciteit bij herhaalde dosering met ratten en honden die maximaal 3 maanden duurden, hadden de voornaamste doelorgaaneffecten betrekking op de volgende systemen: gastro- intestinaal (braken, fecale veranderingen, verstopping), hematopoëtisch (beenmerghypocellulariteit), cardiovasculair (gemengde ionkanaalblokker, afname van hartfrequentie en bloeddruk, toename van lvedp, qrs- en pr-intervallen en afname van myocardcontractiliteit) of reproductie (testiculaire degeneratie van pachytene spermatocyten, eencellige necrose van ovariumfollikels).

English

in rat and dog repeat-dose toxicity studies up to 3-month duration, the primary target organ effects were related to the gastrointestinal (emesis, faecal changes, congestion), haematopoietic (bone marrow hypocellularity), cardiovascular (mixed ion channel blocker, decreased heart rate and blood pressure, increased lvedp, qrs and pr intervals, and decreased myocardial contractility), or reproductive (testicular pachytene spermatocyte degeneration, single-cell necrosis of ovarian follicles) systems.

Last Update: 2017-04-26
Usage Frequency: 1
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