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in view of the therapeutic uses of erythromycin and lincomycin and also of the inducible resistance properties inherent in erythromycin and oleandomycin, it is proposed that :
i betragtning af den terapeutiske anvendelse af erythromycin og lincomycin samt oleandomycins og erythromycins evne til at inducere resistens foreslås, at
cox-2 is the inducible form of the enzyme and is responsible for the production of mediators including pge2 which induce pain, inflammation or fever.
cox-2 er den inducerbare form af enzymet og er ansvarlig for dannelsen af mediatorer, herunder pge2, der inducerer smerter, inflammation eller feber.
cox-2 on the other hand, is mainly inducible and synthesized by macrophages and inflammatory cells after stimulation by cytokines and other mediators of inflammation.
cox-2, derimod, er hovedsagelig inducerbart og syntetiseres af makrofager og inflammatoriske celler efter stimulation med cytokiner og andre inflammationsmediatorer.
elvitegravir is a modest inducer and may have the potential to induce cyp2c9 and/or inducible ugt enzymes; as such it may decrease the plasma concentration of substrates of these enzymes.
elvitegravir er en moderat inducer og kan have potentiale til at inducere cyp2c9 og/eller inducerbare ugt-enzymer, og i derved reducere plasmakoncentrationen af substrater for disse enzymer.
in addition to regulating cell cycle proteins, mtor can regulate translation of the hypoxia-inducible factors, hif-1 and hif-2 alpha.
udover at regulere cellecyklusproteiner, kan mtor regulere translationen af de hypoxi-inducerende faktorer, hif-1 og hif-2 alfa.
cyp1a1 catalyses the formation of riociguat’s main metabolite in liver and lungs and is known to be inducible by polycyclic aromatic hydrocarbons, which, for example, are present in cigarette smoke.
cyp1a1 katalyserer dannelsen af riociguats primære metabolit i lever og lunger, og vides at kunne induceres af polycykliske aromatiske kulbrinter, som der f.eks. findes i cigaretrøg.
1 some strains produce inducible or stably derepressed chromosomally-encoded cephalosporinases and esbls (extended spectrum beta-lactamases) and thus are clinically resistant to cephalosporins.
2.
in clinical trials in patients with psoriasis, apremilast decreased lesional skin epidermal thickness, inflammatory cell infiltration, and expression of pro-inflammatory genes, including those for inducible nitric oxide synthase (inos), il-12/il-23p40, il-17a, il-22 and il-8.
i kliniske studier hos patienter med psoriasis reducerede apremilast epidermis-fortykkelse af hudlæsionerne, inflammatorisk celleinfiltration og ekspressionen af proinflammatoriske gener, herunder generne for inducerbart nitrogenoxidsyntase (inos), il-12/il- 23p40, il-17a, il-22 og il-8.