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21 hepatobiliary disorders: jaundice (intrahepatic cholestatic jaundice)
21 gastrointestinale sygdomme:pancreatitis, anoreksi, diarré, obstipation, gastrisk irritation, sialadenitis, appetitløshed,
hepatic impairment thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, as it may cause intrahepatic cholestasis, and since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
thiazider bør anvendes med forsigtighed til patienter med nedsat leverfunktion eller progressiv leversygdom, da mindre ændringer i væske - og elektrolytbalancen kan udløse hepatisk koma.
evaluation of recovery animals indicated that all treatment-related findings were reversible after 8 weeks of dosing cessation, except for proliferation of intrahepatic bile ducts observed in 1 animal in the 1 mg/kg/day group.
evaluering af dyr i bedring indikerede, at alle behandlingsrelaterede fund var reversible 8 uger efter doseringsophør undtagen proliferation af intrahepatiske galdeveje observeret hos 1 dyr i gruppen med 1 mg/kg/dag.