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hypercornification of the epithelial lining of the pilosebaceous unit leads to shedding of corneocytes into the duct and blockage by keratin and excess sebum.
dette efterfølges af dannelsen af et komedon og eventuelt af inflammatoriske læsioner.
efficacy hypercornification of the epithelial lining of the pilosebaceous unit leads to shedding of corneocytes into the duct and blockage by keratin and excess sebum.
effekt forøget horndannelse af talgkirtlens epitel medfører spredning af corneocytter i udførselsgangen og tilstopning med keratin og overskudstalg.
4-oxo-isotretinoin has been shown in a clinical study to be a significant contributor to the activity of isotretinoin (reduction in sebum excretion rate despite no effect on plasma levels of isotretinoin and tretinoin).
i et klinisk studie har 4- oxo- isotretinoin vist sig at bidrage signifikant i aktiviteten af isotretinoin (reduktion af ekskretionshastigheden af sebum selv om plasmaniveauerne af isotretinoin og tretinoin ikke påvirkes).