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caution should be exercised when prescribing thymanax with moderate cyp1a2 inhibitors (e. g. propranolol, grepafloxacine, enoxacine) which may result in increased exposure of agomelatine.
hierdoor kan de blootstelling van agomelatine toenemen.
Last Update: 2011-10-23
Usage Frequency: 1
Quality:
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while there was no specific safety signal in the 800 patients treated in combination with oestrogens, caution should be exercised when prescribing agomelatine with other moderate cyp1a2 inhibitors (e. g. propranolol, grepafloxacine, enoxacine) until more experience has been gained (see section 4.4).
hoewel er geen specifieke veiligheidsaspecten werden vastgesteld bij de 800 patiënten die in combinatie met het oestrogeen werden behandeld, is voorzichtigheid geboden bij het voorschrijven van agomelatine met andere gematigde cyp1a2- remmers (bv. propranolol, grepafloxacine, enoxacine), totdat er meer ervaring hiermee is (zie rubriek 4.4).
Last Update: 2012-04-11
Usage Frequency: 2
Quality:
