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a safety pharmacology study with intravenous administration of lacosamide in anesthetized dogs showed transient increases in pr interval and qrs complex duration and decreases in blood pressure most likely due to a cardiodepressant action.
farmakoloogilised ohutusuuringud näitasid anesteseeritud koertel lakosamiidi veenisisese manustamise korral mööduvat pr-intervalli ja qrs-kompleksi kestvuse suurenemist ning vererõhu langust nähtavasti kardiodepressiivse toime tõttu.
Last Update: 2017-04-26
Usage Frequency: 7
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in anesthetized dogs and cynomolgus monkeys, at intravenous doses of 15-60 mg/kg, slowing of atrial and ventricular conductivity, atrioventricular block and atrioventricular dissociation were seen.
anesteesias koertel ja cynomolgus ahvidel leiti ravimi veenisisesel manustamisel annuses 15- 60 mg/kg südame kodade ja vatsakeste elektrijuhte aeglustumine, atrioventrikulaarne blokaad ja atrioventrikulaarne dissotsiatsioon.
Last Update: 2017-04-26
Usage Frequency: 5
Quality:
in the toxicity studies, the plasma concentrations of lacosamide obtained were similar or only marginally higher than those observed in patients, which leaves low or non-existing margins to human exposure a safety pharmacology study with intravenous administration of lacosamide in anesthetized dogs showed transient increases in pr interval and qrs complex duration and decreases in blood pressure most likely due to a cardiodepressant action.
farmakoloogilised ohutusuuringud näitasid anesteseeritud koertel lakosamiidi veenisisese manustamise korral mööduvat pr- intervalli ja qrs- kompleksi kestvuse suurenemist ning vererõhu langust nähtavasti kardiodepressiivse toime tõttu.
Last Update: 2011-10-23
Usage Frequency: 1
Quality:
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