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bone marrow cellularity
luuüdi rakulisus
Last Update: 2017-04-26
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if the bone marrow cellularity is > 50 %, no dose adjustments should be made.
kui luuüdi rakulisus on > 50%, ei tohi annust kohandada.
Last Update: 2017-04-26
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in rats decreased cellularity of the bone marrow and thymic atrophy were observed only in the carcinogenicity study.
rottidel esines ainult kantserogeensuse uuringus luuüdi tsellulaarsuse vähenemist ja tüümuse atroofiat.
Last Update: 2017-04-26
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however, if recovery has not been achieved within 14 days, bone marrow cellularity should be determined.
kui taastumist ei ole 14 päeva jooksul saavutatud, tuleb määrata luuüdi rakulisus.
Last Update: 2017-04-26
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if bone marrow cellularity is ≤ 50%, treatment should be delayed and the dose reduced according to the following table:
kui luuüdi rakuline tihedus on ≤ 50%, tuleb ravi edasi lükata ja vähendada annust vastavalt järgmisele tabelile:
Last Update: 2011-10-23
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in a study in dogs in which trametinib and dabrafenib were given in combination for 4 weeks, signs of gastrointestinal toxicity and decreased lymphoid cellularity of the thymus were observed at lower exposures than in dogs given trametinib alone.
uuringus koertel, milles kasutati 4 nädala jooksul tramentiniibi ja dabrafeniibi kombinatsiooni, täheldati madalate plasmakontsentratsioonide juures seedetrakti toksilisust ja lümfikoe vähenemist tüümuses, võrreldes trametiniibi monoteraapiaga koertel.
Last Update: 2017-04-26
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in a study in dogs in which trametinib and dabrafenib were given in combination for 4 weeks, signs of gastro-intestinal toxicity and decreased lymphoid cellularity of the thymus were observed at lower exposures than in dogs given trametinib alone.
uuringus koertel, milles kasutati 4 nädala jooksul tramentiniibi ja dabrafeniibi kombinatsiooni, täheldati madalate plasmakontsentratioonide juures seedetrakti toksilisust ja lümfikoe vähenemist tüümuses, võrreldes trameteniibi monoteraapiaga koertel.
Last Update: 2017-04-26
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findings of note included treatment related adverse reactions of the liver in rats (characterized by centrilobular congestion, abnormal cell division, hepatocellular necrosis and pericentral vein/interlobular fibrosis) which may be related to circulatory disturbances and changes indicative of increased haematopoiesis (high reticulocyte ratio and/or platelet count, increased cellularity of the haematopoietic cells in the femoral and sternal bone marrow, and/or extramedullary haematopoiesis in the liver and spleen).
tähelepanu väärivate leidude hulka kuulusid raviga seotud kõrvaltoimed rottide maksas (mida iseloomustavad tsentriloburaalne pais, rakkude ebanormaalne jagunemine, hepatotsellulaarne nekroos ja peritsentraalse veeni / interloobiumi fibroos), mis võivad olla seotud tsirkulatoorsete häiretega ja suurenenud vereloomet näitavate muutustega (suur retikulotsüütide suhe ja/või suur trombotsüütide arv, vereloomerakkude tsellulaarsuse suurenemine reieluu ja rinnaku luuüdi materjalis ja/või ekstramedullaarne vereloome maksas ja põrnas).
Last Update: 2017-04-26
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