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the polyglutamate forms are retained in cells and are even more potent inhibitors of ts and garft.
polügluglutamaadid jäävad rakku ning on isegi tugevamad ts ja garft inhibiitorid.
Last Update: 2017-04-26
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once in the cell, pemetrexed is rapidly and efficiently converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase.
rakus konverteeritakse pemetrekseed kiiresti ja laialdaselt ensüüm folüülpolüglutamaatsüntetaasi abil polüglutamaatideks.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
upon being distributed into body tissues, high concentrations particularly in liver, kidneys and spleen in form of polyglutamates can be found, which can be retained for weeks or months.
jaotumisel kudedesse satub see polüglutamaatidena suurtes kontsentratsioonides eriti maksa, neerudesse ja põrna, kus see võib püsida nädalaid ja kuid.
Last Update: 2017-04-26
Usage Frequency: 1
Quality: