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an analysis of tropism following failure of celsentri therapy with cxcr4 -using virus, demonstrated that the virus population reverted back to ccr5 tropism in the majority of patients during follow up after discontinuation of celsentri.
tropismi analüüs pärast celsentri- ravi ebaõnnestumist cxcr4- kasutavate viiruste tõttu, et enamusel patsientidest pöördus viirusepopulatsioon pärast celsentri- ravi lõpetamist tagasi ccr5ga seondumise juurde.
the mean increase in cd4+ cell count from baseline in patients who failed with a change in tropism result to dual/ mixed tropic or cxcr4, in the celsentri 300 mg twice daily + obt (+56 cells/ mm3) group was greater than that seen in patients failing obt alone (+13.8 cells/ mm3) regardless of tropism.
15 celsentri 300 mg kaks korda päevas + obt (+56 rakku/ mm3) rühmas, kui patsientidel, kelle ravi ebaõnnestus ainult obt- ga (+13, 8 rakku/ mm3) sõltumata seondumisest.