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the compound potentially induces photogenotoxicity after subsequent irradiation or light exposure which is obviously related to the induction of porphyrin synthesis.
yhdiste voi mahdollisesti indusoida fotogenotoksisuutta hoidon jälkeisen säteilytykselle tai valonsäteille altistuksen jälkeen, mikä ilmeisesti on yhteydessä porfyriinisynteesin induktioon.
Last Update: 2017-04-26
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when tested for potential photogenotoxicity in vitro in a chinese hamster ovary (cho) cell line, granisetron increased the percentage of cells with chromosome damage following photoirradiation.
kun granisetronia testattiin mahdollisen fotogenotoksisuuden varalta in vitro kiinalaisen hamsterin munasarjan (cho) solulinjassa, granisetroni lisäsi kromosomivaurioituneiden solujen prosentuaalista määrää valosäteilyttämisen jälkeen.
Last Update: 2017-04-26
Usage Frequency: 1
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kersten, b., zhang, j., brendler schwaab, s.y., kasper, p. and müller, l. (1999), the application of the micronucleus test in chinese hamster v79 cells to detect drug-induced photogenotoxicity, mutation res. 445, 55-71.
kersten, b., zhang, j., brendler schwaab, s. y., kasper, p. ja müller, l. (1999). the application of the micronucleus test in chinese hamster v79 cells to detect drug-induced photogenotoxicity. mutation res. 445, s. 55–71.
Last Update: 2014-11-21
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