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[non-neoplastic effects, no-observed-adverse-effect level (noael) = 2.0 mg/kg-bw per day] 2.4.3.5 genotoxicity acrolein induces gene mutations in both bacteria (hemminiki et al., 1980; lijinsky and andrews, 1980; hales, 1982; lutz et al., 1982; haworth et al., 1983; marnett et al., 1985; foiles et al., 1989; parent et al., 1996) and mammalian cells in culture (smith et al., 1990), as well as structural chromosomal aberrations in chinese hamster ovary (cho) cells (au et al., 1980) and sister chromatid exchanges in cho cells (au et al., 1980; galloway et al., 1987) and cultured human lymphocytes (wilmer et al., 1986).
[effets non néoplasiques, concentration sans effet nocif observé (cseno) = 2,0 mg/kg-m.c. par jour] 2.4.3.5 génotoxicité l'acroléine induit des mutations géniques tant chez les bactéries (hemminiki et al., 1980; lijinsky et andrews, 1980; hales, 1982; lutz et al., 1982; haworth et al., 1983; marnett et al., 1985; foiles et al., 1989; parent et al., 1996) que chez les cellules de mammifère en culture (smith et al., 1990); elle provoque également des aberrations chromosomiques structurales dans les cellules d'ovaires de hamsters chinois (ohc) (au et al., 1980) et l'échange de chromatides súurs dans les cellules (ohc) (au et al., 1980; galloway et al., 1987) et dans les lymphocytes humains de culture (wilmer et al., 1986).
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