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defibrotide also inhibits the expression of heparanase contributing to extracellular matrix integrity and thereby tissue homeostasis.
Η δεφιβρωτίδη αναστέλλει επίσης την έκφραση ηπαρανάσης, συμβάλλοντας έτσι στην ακεραιότητα της εξωκυτταρικής ύλης και, κατά συνέπεια, στην ομοιόσταση των ιστών.
Last Update: 2017-04-26
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the epithelial cells on the external surface of the body typically secrete an extracellular matrix in the form of a cuticle.
Τα επιθηλιακά κύτταρα στην εξωτερική επιφάνεια του σώματος συνήθως εκκρίνουν μια εξωκυτταρική μήτρα υπό τη μορφή επιδερμίδας.
Last Update: 2016-03-03
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a further mechanism of action of natalizumab may be to suppress ongoing inflammatory reactions in diseased tissues by inhibiting the interaction of α4-expressing leukocytes with their ligands in the extracellular matrix and on parenchymal cells.
Ένας επιπρόσθετος μηχανισμός δράσης του natalizumab ενδέχεται να είναι η καταστολή των υπό εξέλιξη φλεγμονωδών αντιδράσεων σε νοσούντες ιστούς μέσω της αναστολής της αλληλεπίδρασης των λευκοκυττάρων α4-εκφραστών με τους συνδέτες τους στον εξωκυττάριο χώρο και στα παρεγχυματικά κύτταρα.
Last Update: 2017-04-26
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the contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels.
Οι συσταλτικές διαδικασίες του καρδιακού και αγγειακού λείου μυός εξαρτώνται από την είσοδο των εξωκυττάριων ιόντων ασβεστίου σε αυτά τα κύτταρα διαμέσου συγκεκριμένων διαύλων ιόντων.
Last Update: 2017-04-26
Usage Frequency: 15
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a key contributing factor to the pathogenesis of ph is the reduced elasticity and patency of the pulmonary vascular system, characterized by an imbalance of vasoconstrictive / vasodilatory mediators and increased proliferation of cells within the pulmonary arterial and capillary vessel walls and extracellular matrix
Ένας βασικός παράγοντας που συμβάλλει στην παθογένεση της ΡΗ είναι η μειωμένη ελαστικότητα και η ευρυχωρία του πνευμονικού αγγειακού συστήματος, που χαρακτηρίζεται από ανισορροπία αγγειοσυσταλτικών / αγγειοδιασταλτικών μεσολαβητών και αυξημένου πολλαπλασιασμού κυττάρων εντός των τοιχωμάτων των πνευμονικών αρτηριακών και τριχοειδών αγγείων και της εξωκυτταρικής μήτρας
Last Update: 2020-08-05
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one locus, the lpp or lipoma-preferred partner gene, is involved in the adhesion of extracellular matrix to the cell surface, and a minor variant (snp = rs1464510) increases the risk of disease by approximately 30%.
Ένας γενετικός τόπος,ο lpp ή lipoma-preferred partner gene εμπλέκεται στην προσκόλληση του εξωκυτταρικού πλέγματος στην επιφάνεια του κυττάρου και μια δευτερεύουσα παραλλαγή (snp = rs1464510) αυξάνει τον κίνδυνο της νόσου κατά 30% περίπου.
Last Update: 2016-03-03
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===thecal===the granulosa cells, in turn, are enclosed in a thin layer of extracellular matrix – the follicular basement membrane or basal lamina ("fibro-vascular coat" in picture).
===theca===Τα κύτταρα granulosa, στη συνέχεια, εσωκλείονται σε ένα λεπτό στρώμα extracellular μήτρα - η θυλακοειδής μεμβράνη υπογείων ή το βασικό έλασμα (fibro-vascular coat(στην εικόνα).
Last Update: 2016-03-03
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1) vascular disease such as stroke or peripheral arterial disease it takes its origins from atherosclerosis which in turn rises from endothelial damage and inflammation. now the who has arteriosclerosis labeled as the number one cause of death globally which translates to about 31 worldwide. 2) now a little bit about bilirubin famously known as a metabolic waste byproduct of heme catabolism but it's time to gain recognition for its potent antioxidant , anti-inflammatory and neuroprotective properties. 3) so why are we interested in looking at the association, i believe that interest begins and arises from the look at the pathophysiology and i'll begin that briefly talking about atherosclerosis which itself starts by the deposition of ldl and other apo-lipoprotein containing lipids and the subendothelial space, then those lipids get oxidized, which has several crucial effects: down regulates the production of nitric oxide which has a crucial basic production of nitric oxide and it has a crucial effect in platelet aggregation and vascular stiffness, it causes an influx of monocytes and lymphocytes via the complex interplay between adhesion molecules such as selectins and integrins and also upregulates activity of metalloproteinase enzymes which breakdown the elastic fibers of the vessels and also increase vascular stiffness. all this influx of inflammatory cells in the deposition of cellular matrix causes plaque formation which in turn it once it ruptures it causes thrombus formation and occludes the vessel. 4) now in comes bilirubin right from the start it decreases the lipid levels solubilizes cholesterol and increases excretion via the bile. has antioxidant properties via the redox reactions of the heme oxygen is 1 enzyme which preserves nitric oxide which is very crucial it also inhibits systemic inflammation down regulates the expression of cell division molecules and the activity of matrix metalloproteinase enzymes and all that combined inhibits platelet aggregation which inhibits vessel collusion. 5) here we see them side by side: every pathophysiological step of atherosclerosis is antagonized by the protective effects of bilirubin. 6) so having all this information at hand why go ahead and perform a systematic review i believe the most obvious answer to that begin with is that delivers a clear and comprehensive overview of the evidence we have at hand it identifies any research at so any missing or insufficient information that limits our ability to reach a conclusion since arteriosclerotic cardiovascular disease is also increasing rapidly and a lot of simple medications like aspirin statins another blood pressure agents still remain affordable to the world, it's crucial draft new treatments and preventive methods to serve as a guide for positions and lastly highlight any methodological concerns found in the studies that could be addressed in future studies. 7) now this review was conducted according to the personal guidelines as shown here on the right hand side three databases reduced pub med, scopus and cochrane. unfortunately cochrain did not yield any results all the results came from pub med scopus 188 articles plus one additional article reference from one of the references of the one pub med article. then those were ran for duplicates once duplicates removed 146 articles remain they will run through level one screening providing for six articles those were further crosses to level 2 screening building 36 articles that were used for this review. screening involves inclusion exclusion criteria so briefly each article had to be no more than 10 years old had to be published in the english language the full text had to provide some kind of statistical information hazard ratio alterations confidence intervals or at least any information where these ratios could be calculated from the studies that had to be an rct or observational study. no reviews or meta-analysis were allowed and lastly the article had to assess some kind of association between serum total bilirubin and cvd.
1) Αγγειακή νόσος όπως εγκεφαλικό επεισόδιο ή περιφερική αρτηριακή νόσος παίρνει τις ρίζες της από την αθηροσκλήρωση η οποία με τη σειρά της προκύπτει από ενδοθηλιακή βλάβη και φλεγμονή. Τώρα το the who έχει απλώς ζημίες που χαρακτηρίζονται ως η νούμερο ένα αιτία θανάτου παγκοσμίως, που μεταφράζεται σε περίπου 31 παγκοσμίως. 2) τώρα λίγα λόγια για τη χολερυθρίνη περίφημα και εξακολουθεί να είναι διάσημα γνωστή ως μεταβολικό απόβλητο υποπροϊόν του καταβολισμού της αίμης, αλλά ήρθε η ώρα να αναγνωριστεί για το ισχυρό αντιοξειδωτικό, αντιφλεγμονώδε
Last Update: 2021-10-06
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