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using an animal model of perinatal hypoxia ischemia, we demonstrated cognitive inflexibility using the attentional set shifting task, a task comparable to the intra extra/dimensional (ied) set shift in humans. additionally, we showed that the cognitive inflexibility in this model was correlated to pfc atrophy and dopaminergic dysregulation also in the pfc, reflecting the profile reported in adhd individuals (25).
our rodent study suggests that perinatal hypoxia-ischemia associates with both impaired cognitive flexibility and altered pfc da signaling
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