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6-desmethyl amide cleavage product sulfate.
6-desmetýlamíð klofningsafurðarsúlfat.
Last Update: 2017-04-26
Usage Frequency: 1
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the cleavage of these viral polyproteins is essential for the maturation of infectious virus.
klofnun þessara veirufjölpróteina er nauðsynlegt þroskaferli veirunnar svo hún sé smitandi.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
galsulfase is comprised of 495 amino acids after cleavage of the n-terminus.
galsúlfasi samanstendur af 495 amínósýrum eftir að n- endinn hefur verið klofinn.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
reteplase is a recombinant plasminogen activator that catalyzes the cleavage of endogenous plasminogen to generate plasmin.
reteplasi er raðbirgða plasmínógen hvati, sem hvetur klofnun plasmínógens sem framleitt er í líkamanum og myndar plasmín.
Last Update: 2017-04-26
Usage Frequency: 1
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metabolic pathways of vismodegib in humans include oxidation, glucuronidation, and an uncommon pyridine ring cleavage.
meðal umbrotsferla vismodegibs hjá mönnum eru oxun, glúkúrónídering og sjaldgæft rof á pýridín hring.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
eltrombopag is primarily metabolised through cleavage, oxidation and conjugation with glucuronic acid, glutathione, or cysteine.
eltrombópag er aðallega umbrotið með klofningi, oxun og tengingu við glúkúrónsýru, glútaþíón eða systein.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
the piperaquine major metabolites were a carboxyl acid cleavage product, and a mono-n-oxidated product.
helstu umbrotsefni píperakíns voru afurð karboxýlsýruklofnunar og ein-n-oxuð afurð.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
the cleavage of the prodrug dabigatran etexilate by esterase-catalysed hydrolysis to the active principle dabigatran is the predominant metabolic reaction.
klofnun forlyfsins dabigatran etexílats fyrir tilstilli esterasahvataða vatnsrofs yfir í virkan þátt dabigatrans er meginumbrotsleiðin.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
inhibition of hiv protease prevents cleavage of the gag-pol polyprotein resulting in the production of immature, non-infectious virus.
hömlun á hiv proteasa kemur í veg fyrir klofning á gag-pol fjölpróteininu og leiðir þannig til myndunar óþroskaðra veira sem ekki valda sýkingu.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
binding of trastuzumab to her2 inhibits ligand-independent her2 signalling and prevents the proteolytic cleavage of its extracellular domain, an activation mechanism of her2.
binding trastuzúmabs við her2 kemur í veg fyrir virkjun her2 viðtakans og hindrar bindils/ hvata-óháða (ligand independent) boðmiðlun her2.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
cyp17 catalyses the conversion of pregnenolone and progesterone into testosterone precursors, dhea and androstenedione, respectively, by 17α-hydroxylation and cleavage of the c17,20 bond.
cyp17 hvetur umbreytingu pregnenólóns og prógesteróns í testósterón forstigsefni, dhea og andróstendíón, í hvoru tilviki fyrir sig, með 17α-hýdroxýleringu og rofi á c17,20 tenginu.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
a number of cleavage (hydrolysis) sites on the human insulin molecule have been proposed; none of the metabolites formed following the cleavage are active.
getið hefur verið til um nokkra klofningsstaði (vatnsrof) á mannainsúlínsameindinni; engin umbrotsefni sem myndast í kjölfar klofnings eru virk.
Last Update: 2017-04-26
Usage Frequency: 1
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another pathway involves oxidative cleavage of the ether bond forming ‘o-debenzylated safinamide’ (nw-1199).
annað ferli felur í sér oxunarklofnun á etertengjum sem mynda „o-debensýlað safinamíð“ (nw-1199).
Last Update: 2017-04-26
Usage Frequency: 1
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ketoconazole inhibits primarily the activity of 17-hydroxylase, but it also inhibits 11-hydroxylation steps, and at higher doses the cholesterol side-chain cleavage enzyme.
ketókónazól hamlar fyrst og fremst virkni 17-hýdroxýlasa, en hamlar einnig 11-hýdroxýltengingarskrefum og við stærri skammta hamlar það klofnunarensími kólesteról hliðarkeðju.
Last Update: 2017-04-26
Usage Frequency: 1
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animal studies have shown that severely reduced hepatic blood flow decreases exposure of pth to the principal cleavage system (kupffer cells) and consequently clearance of pth(1-84).
dýrarannsóknir hafa sýnt að mikið skert blóðflæði um lifur lækkar streymi parahtýróíðhormóns til aðalumbrotskerfa (kupffer frumur) og þar af leiðandi úthreinsun paratýróíðhormóns (1-84).
Last Update: 2017-04-26
Usage Frequency: 1
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