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in vitro studies have shown that pemetrexed behaves as a multitargeted antifolate by inhibiting thymidylate synthase (ts), dihydrofolate reductase (dhfr), and glycinamide ribonucleotide formyltransferase (garft), which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotides.
studi in vitro hanno dimostrato che il pemetrexed agisce come agente antifolato multi-target inibendo la timidilato sintetasi (ts), la diidrofolato reduttasi (dhfr) e la glicinamide- ribonucleotide-formil transferasi (garft) che sono enzimi chiave folato-dipendenti per la biosintesi de novo dei nucleotidi timidina e purina.
