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ubiquitination
ubiquitinazione
Last Update: 2014-12-09
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protein ubiquitination
ubiquitinazione
Last Update: 2014-12-09
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ubiquitination activating enzyme e1
enzimi attivanti l'ubiquitina
Last Update: 2014-12-09
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in the presence of lenalidomide, cereblon binds substrate proteins aiolos and ikaros which are lymphoid transcriptional factors, leading to their ubiquitination and subsequent degradation resulting in cytotoxic and immunomodulatory effects.
in presenza di lenalidomide, cereblon si lega alle proteine substrato aiolos e ikaros, che sono fattori di trascrizione linfoidi, provocandone l’ubiquitinazione e la successiva degradazione, con conseguenti effetti citotossici e immunomodulatori.
Last Update: 2017-04-26
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