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in monkeys, administration of duotrav twice–daily was shown to induce increased palpebral fissure and to increase iris pigmentation similar to that observed with ocular administration of prostanoids.
pērtiķiem duotrav ievadīšana divas reizes dienā palielināja plakstiņa kroku (rima palpebrarum) un pastiprināja varavīksnenes pigmentāciju, tāpat kā acīs ievadīti prostanoīdi.
Last Update: 2017-04-26
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no specific drug-drug interactions with soluble guanylate cyclase stimulators or prostanoids are anticipated based on the known biotransformation data (see section 5.2).
pamatojoties uz zināmajiem datiem par biotransformāciju, specifiska šo zāļu mijiedarbība ar šķīstošās guanilātciklāzes stimulatoriem vai prostanoīdiem nav gaidāma (skatīt 5.2. apakšpunktu).
Last Update: 2017-04-26
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cox-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever.
cox-2 ir enzīma izoforma, kuru inducē pirmsiekaisuma stimuli, un tika noskaidrots, ka tas ir primāri atbildīgs par sāpju, iekaisuma un drudža prostanoīdo mediatoru sintēzi.
Last Update: 2017-04-26
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