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moreover, unlike anthracyclines or anthracenediones, pixantrone directly alkylates dna forming stable dna adducts and cross-strand breaks.
turklāt atšķirībā no antraciklīniem vai antracēndioniem piksantrons tieši alkilē dns, veidojot stabilus dns savienojumus un dubultu pavedienu atstarpes.
in replicating cells this leads to dna double strand breaks (dsbs) when replication forks meet the parp-dna adduct.
vairošanās stadijā esošām šūnām tas izraisa dns dubultspirāles pārrāvumus, kad replikācijas dakšas sastopas ar parp-dns kompleksu.