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lamivudine-tp does not interfere with normal cellular deoxynucleotide metabolism.
lamivudine-tp ma jfixkilx il-metaboliżmu deoxynucleotide ċellulari normali.
Last Update: 2017-04-26
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ribonucleotide reductase inhibition with reduction of cellular deoxynucleotide triphosphate (dntp) pools.
inibizzjoni ta’ ribonucleotide reductase bi tnaqqis ta’ għadajjar ta’ cellular deoxynucleotide triphosphate (dntp).
Last Update: 2017-04-26
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its antitumour activity is believed to be due to 3 mechanisms: • dna polymerase α inhibition resulting in termination of dna chain elongation and/ or dna synthesis / repair. • ribonucleotide reductase inhibition with reduction of cellular deoxynucleotide triphosphate (dntp) pools.
l- attività tiegħu ta ’ kontra t - tumuri hi maħsuba li hi riżultat ta '3 mekkaniżmi: • inibizzjoni tad- dna polymerase α li jwassal għat- tmiem ta ’ l- elongazzjoni tal- katina tad- dna u/ jew sinteżi/ tiswija tad- dna. • inibizzjoni ta ’ ribonucleotide reductase bi tnaqqis ta ’ għadajjar ta ’ cellular deoxynucleotide triphosphate (dntp). • tħarbit ta ’ l- integrità tar- rita mitokondrjali bil- ħruġ ta ’ cytochrome c u fatturi oħra proapoptotiċi li jirriżultaw fil- mewt programmata taċ- ċellula anki fl- limpoċiti li ma jkunux diviżi.
Last Update: 2011-10-23
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