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both timp and mtimp are inhibitors of phosphoribosyl pyrophosphate amidotransferase, an enzyme which is important in de novo purine synthesis.
timp aj mtimp sú inhibítory fosforibozylpyrofosfátamidotransferázy, enzýmu, ktorý je dôležitý pre syntézu purínu de novo.
Last Update: 2017-04-26
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the first step is catalysed by hypoxanthine-guanine phosphoribosyl transferase yielding thioinosine monophosphate (timp).
prvý krok je katalyzovaný hypoxantín-guanín-fosforibozyltransferázou, pričom sa vytvorí tioinozínmonofosfát (timp).
Last Update: 2017-04-26
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10 in the ames test or the chinese hamster ovary/ hypoxanthine-guanine phosphoribosyl transferase (cho/ hgprt) gene mutation assay.
ukázalo sa, že paclitaxel je genotoxický in vivo (mikronukleárny test u myší), no nevyvolával mutagenitu v amesovom teste ani na ováriach čínskeho škrečka/ hypoxantín- guanín fosforibozyl transferáza (cho/ hgprt).
Last Update: 2011-10-23
Usage Frequency: 1
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on theoretical grounds, therefore, it should be avoided in patients with rare hereditary deficiency of hypoxanthine-guanine phosphoribosyl-transferase (hgprt) such as lesch-nyhan and kelley- seegmiller syndrome.
z toho dôvodu sa teoreticky nemá podávať u pacientov so zriedkavou dedičnou deficienciou hypoxantín - guanín- fosforibozyltransferázy (hgprt) ako je lesch- nyhanov a kelley- seegmillerov syndróm.
Last Update: 2012-04-12
Usage Frequency: 4
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