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4 hingamise pärssimine:
4 suboxone may cause drowsiness, particularly when taken together with alcohol or central nervous system depressants (such as tranquilisers, sedatives or hypnotics) (see section 4.5).
- neerupealiste funktsiooni pärssimine
of blood clotting system -heart rhythm problems including very fast heartbeat, very slow heartbeat, fainting -depressed function of the adrenal gland
maohappe sekretsiooni pärssimine võib põhjustada nilotiniibi ekspositsiooni vähenemist.
suppression of gastric acid secretion might result in lower exposure to nilotinib.
kõige tähtsam toime oli annusest ja annuse intervallist sõltuv pöörduv hematopoeesi pärssimine.
in repeat-dose studies of up to 6 months in duration in mice and dogs, the principal finding was schedule and dose-dependent haematopoietic suppression which was reversible.