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terved isikud
healthy subjects
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
terved
whole
Last Update: 2014-11-21
Usage Frequency: 14
Quality:
terved isikud on talunud erlotiniibi ühekordseid suukaudseid annuseid kuni 1000 mg ja vähipatsiendid kuni 1600 mg.
single oral doses of tarceva up to 1000 mg erlotinib in healthy subjects, and up to 1600 mg in cancer patients have been tolerated.
põhjalikus qtc uuringus, kus terved isikud said kuni 40 mg ööpäevas, ei täheldatud qtc-intervalli pikenemise ilminguid.
in a thorough qtc study in healthy subjects at doses up to 40 mg daily, no potential for the prolongation of the qtc interval was observed.
plasmakontsentratsioonidel põhinev steady- state (püsioleku) jaotusruumala on ligikaudu 1300 liitrit (terved isikud).
the steady-state volume of distribution based on plasma concentrations is approximately 1300 l (healthy subjects).
suures topeltpimedas randomiseeritud võrdlevas uuringus said terved isikud kolmest annusest koosneva esmase kuuri fendrixi (n=713) või müügiloleva hepatiit b vaktsiiniga (n=238) kuudel 0, 1 ja 2.
in a large double-blind randomised comparative study, healthy subjects were enrolled to receive a three dose primary course of fendrix (n= 713) or a commercially available hepatitis b vaccine (n= 238) at 0, 1, 2 months.
keskmine jaotusruumala 100 mikromooli/kg annuse korral oli neerukahjustuseta patsientidel (terved isikud ja kns või maksapatoloogiaga patsiendid) 158,7 ± 29,0 kuni 214,3 (ulatus 116,4 - 295,0) ml/kg.
mean volume of distribution at the 100 micromol/kg dose in non-renally impaired patients (including both normal subjects and patients with cns or liver pathology) was 158.7 ± 29.0 to 214.3 (range 116.4 to 295.0) ml/kg.