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thelinin ja ortho-novum 1/35 -valmisteen (1 mg noretindronia/0, 035 mg etinyyliestradiolia) samanaikainen anto johti suurentuneeseen (59%) altistukseen etinyyliestradiolille (cyp3a4/5-entsyymin substraatti) ja noretindronille (cyp3a4/5-entsyymin substraatti) (47%) .
concomitant administration of thelin and ortho-novum 1/35 (1 mg norethindrone/0.035 mg ethinyl estradiol) resulted in increases in exposure to ethinyl estradiol (substrate of cyp3a4/5) and norethindrone (cyp3a4/5) of 59% and 47%, respectively.
Last Update: 2008-03-04
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