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· pbp-proteiinien heikentynyt kefuroksiimiaffiniteetti
· reduced affinity of penicillin-binding proteins for cefuroxime
Last Update: 2008-03-04
Usage Frequency: 3
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· ulkokalvon läpäisemättömyys, mikä vaikeuttaa kefuroksiimin pääsyä pbp-proteiiniin
12· outer membrane impermeability, which restricts access of cefuroxime to penicillin binding
Last Update: 2008-03-04
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escherichia coli -bakteerissa sillä on suurin affiniteetti pbp- proteiineihin 2 ja 3.
in escherichia coli, affinity is strongest to pbps 2 and 3.
Last Update: 2017-04-26
Usage Frequency: 4
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lääkeaine sitoutuu ensiksi soluseinän penisilliiniä sitovaan proteiiniin (pbp) , jolloin transpeptidaatioreaktio ja peptidoglykaanisynteesi estyvät.
the initial step in drug action consists of binding of the drug to cell receptors, called penicillin-binding proteins.after a -lactam antibiotic has bound to these receptors, the transpeptidation reaction is inhibited and peptidoglycan synthesis is blocked.
Last Update: 2008-03-04
Usage Frequency: 3
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vaikutustapa ertapeneemi estää bakteerin soluseinämän synteesin kiinnittymällä penisilliiniä sitoviin proteiineihin (penicillin binding protein, pbp).
mode of action ertapenem inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (pbps).
Last Update: 2012-04-10
Usage Frequency: 3
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penisilliiniresistentit streptococcus pneumoniae - bakteerit ovat pbp- proteiinien muutosten takia ristiresistenttejä kefalosporiineille (myös kefuroksiimille).
penicillin-resistant streptococcus pneumoniae are cross-resistant to cephalosporins such as cefuroxime through alteration of penicillin binding proteins.
Last Update: 2012-04-10
Usage Frequency: 7
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