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clustered regularly interspaced short palindromic repeat
clustered regularly interspaced short palindromic repeat
Last Update: 2014-12-08
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la présente invention concerne un polynucléotide isolé qui comprend une séquence d'acide nucléique à série crispr (clustered regularly interspaced short palindromic repeat) où au moins un espaceur de la crispr est suffisamment complémentaire d'une partie d'au moins un gène procaryote afin de réduire l'expression du gène procaryote. la présente invention concerne également des utilisations des polynucléotides et de compositions pharmaceutiques qui comprennent les polynucléotides.
an isolated polynucleotide is disclosed. the polynucleotide comprises a clustered, regularly interspaced short palindromic repeat (crispr) array nucleic acid sequence wherein at least one spacer of the crispr is sufficiently complementary to a portion of at least one prokaryotic gene so as to down-regulate expression of the prokaryotic gene. uses of the polynucleotides and pharmaceutical compositions comprising the polynucleotides are also disclosed.
Last Update: 2011-07-27
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