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plasmaspiegel (cmax) sind annähernd dosisproportional.
over the range of 25 to 800 mg, extent of exposure (auc) increases in a dose-proportional manner and the peak plasma concentration (cmax) was roughly dose-proportional.
annähernd 50% dieser patienten erhielten methotrexat.
study vi with 24 week duration, treated 313 adult patients who had an inadequate response to non-steroidal anti-inflammatory drug therapy and of these, approximately 50% were taking methotrexate.