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apa ini masih ada
这个还有吗
Last Update: 2022-02-19
Usage Frequency: 1
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apakah saudara perempuan saya membersi kan dapur
my sister doesn't clean the kitchen
Last Update: 2021-11-20
Usage Frequency: 1
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selama persediaan masih ada
applies multiply
Last Update: 2019-04-18
Usage Frequency: 1
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selama stock masih ada.
while stock is still in stock
Last Update: 2024-06-09
Usage Frequency: 1
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
Last Update: 2014-04-24
Usage Frequency: 1
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berlaku selama persediaan masih ada
while supplies last
Last Update: 2019-04-12
Usage Frequency: 1
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masih ada syarat yang harus dilengkapi
there are still obstacles
Last Update: 2012-04-22
Usage Frequency: 1
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dia menjawab: "masih ada tambahan?"
it will say, "are there any more (to come)?"
Last Update: 2014-07-03
Usage Frequency: 2
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dari 16 laboratorium rujukan, 7 ada di asia, 5 di eropa, 2 di afrika, 1 di amerika utara, dan 1 di australia.
out of the 16 reference laboratories, 7 are in asia, 5 in europe, 2 in africa, 1 in north america and 1 in australia.
Last Update: 2020-08-25
Usage Frequency: 1
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itulah juga alasannya mengapa saudara membayar pajak, sebab pemerintah adalah pegawai allah yang menjalankan tugas yang khusus ini
for for this cause pay ye tribute also: for they are god's ministers, attending continually upon this very thing.
Last Update: 2012-05-06
Usage Frequency: 1
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berapa bersaudara?
how long have you lived in indonesia?
Last Update: 2025-03-05
Usage Frequency: 1
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