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tā kā dimetilfumarātu un monometilfumarātu metabolizē esterāzes, neiesaistoties cyp450 sistēmai, farmakokinētikas novērtēšana cilvēkiem ar aknu darbības traucējumiem nav veikta.
as dimethyl fumarate and monomethyl fumarate are metabolised by esterases, without the involvement of the cyp450 system, evaluation of phamacokinetics in individuals with hepatic impairment was not conducted.
Last Update: 2017-04-26
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perorāli lietots tecfidera (dimetilfumarāts) tiek pakļauts straujai presistēmiskai hidrolīzei esterāžu ietekmē un tiek pārveidots par tā primāro metabolītu, monometilfumarātu, kas arī ir aktīvs.
orally administered tecfidera (dimethyl fumarate) undergoes rapid presystemic hydrolysis by esterases and is converted to its primary metabolite, monomethyl fumarate, which is also active.
Last Update: 2017-04-26
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citi asinsritē konstatējamie metabolīti bija fumārskābe, citronskābe un monometilfumarāts.
other circulating metabolites included fumaric acid, citric acid and monomethyl fumarate.
Last Update: 2017-04-26
Usage Frequency: 1
Quality: