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epilepsijas populācijas farmakokinētikas analīzē tika konstatēts, ka perampanels par 26% samazina okskarbazepīna klīrensu.
in the epilepsy population pharmacokinetic analysis, perampanel was found to decrease the clearance of oxcarbazepine by 26%.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
tomēr prospektīvā pētījumā ar veseliem pieaugušiem brīvprātīgajiem, lietojot 200 mg lamotrigīna un 1200 mg okskarbazepīna, okskarbazepīns nemainīja lamotrigīna metabolismu, un lamotrigīns nemainīja okskarbazepīna metabolismu.
60 doses of 200 mg lamotrigine and 1200 mg oxcarbazepine, oxcarbazepine did not alter the metabolism of lamotrigine and lamotrigine did not alter the metabolism of oxcarbazepine.
Last Update: 2012-04-10
Usage Frequency: 2
Quality:
tādēļ pacientiem, kas vienlaikus saņem okskarbazepīna terapiju, jāizmanto ārstēšanas shēma lamotrigīna lietošanai papildinošā terapijā bez valproāta un bez lamotrigīna glikuronizācijas inducētājiem (skatīt apakšpunktu 4. 2).
therefore in patients receiving concomitant therapy with oxcarbazepine, the treatment regimen for lamotrigine adjunctive therapy without valproate and without inducers of lamotrigine glucuronidation should be used (see section 4.2).
Last Update: 2012-04-10
Usage Frequency: 2
Quality:
okskarbazepīns
oxcarbazepine
Last Update: 2017-04-26
Usage Frequency: 3
Quality: