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madankollu, ir-rekwiżiti mhumiex dejjem proprozjonali mar-riskji potenzjali, dan ifisser li l-ispejjeż ta' applikazzjoni jistgħu jitqiesu disproporzjonati.
however, the requirements are not always proportional to the potential risks, which mean that the costs of application could be considered disproportionate.
Last Update: 2017-04-06
Usage Frequency: 1
Quality:
fi studji dwar il-firxa tad-doża, denosumab wera farmakokinetika mhux lineari u dipendenti mid- doża, bi tneħħija aktar baxxa b’dożi jew konċentrazzjonijiet ogħla, iżda b’żidiet fl-esponiment ftit jew wisq proprozjonali mad-doża għal dożi ta’ 60 mg jew aktar.
in dose ranging studies, denosumab exhibited non-linear, dose-dependent pharmacokinetics, with lower clearance at higher doses or concentrations, but approximately dose-proportional increases in exposures for doses of 60 mg and greater.
Last Update: 2017-04-26
Usage Frequency: 1
Quality: