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embora, de modo geral, seja necessário recorrer a sistemas de activação metabólica em todos os ensaios in vitro de previsão de potenciais genotóxicos ou carcinogénicos, no domínio da fototoxicologia são ainda raros os exemplos de substâncias químicas que necessitem de transformação metabólica para agirem como fototoxina in vivo ou in vitro.
whereas the use of metabolising systems is a general requirement for all in vitro tests for the prediction of genotoxic and carcinogenic potential, up to now, in the case of phototoxicology, there are only rare examples where metabolic transformation is needed for the chemical to act as a phototoxin in vivo or in vitro.
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