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căile de activare metabolică implică succesiv hidroliza carboxilesterului, catalizată de catepsina a sau carboxilesteraza 1 umane, şi scindarea fosforamidatului de către proteina conţinând triada histidinică, care se leagă de nucleotide, urmate de fosforilare pe calea de biosinteză a nucleotidelor pirimidinice.
the metabolic activation pathway involves sequential hydrolysis of the carboxyl ester moiety catalysed by human cathepsin a or carboxylesterase 1 and phosphoramidate cleavage by histidine triad nucleotide-binding protein 1 followed by phosphorylation by the pyrimidine nucleotide biosynthesis pathway.
Last Update: 2017-04-26
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căile de activare metabolică implică succesiv hidroliza carboxilesterului, catalizată de catepsina a (cata) sau carboxilesteraza 1 (ces1) umane, şi scindarea fosforamidatului de către proteina hint1 (proteină conţinând triada histidinică, care se leagă de nucleotide), urmate de fosforilare pe calea de biosinteză a nucleotidelor pirimidinice.
the metabolic activation pathway involves sequential hydrolysis of the carboxyl ester moiety catalysed by human cathepsin a (cata) or carboxylesterase 1 (ces1) and phosphoramidate cleavage by histidine triad nucleotide-binding protein 1 (hint1) followed by phosphorylation by the pyrimidine nucleotide biosynthesis pathway.
Last Update: 2017-04-26
Usage Frequency: 1
Quality: