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atât timp, cât şi mtimp sunt inhibitori ai fosforibozil pirofosfat amidotransferazei, o enzimă importantă în sinteza de novo a purinei.
both timp and mtimp are inhibitors of phosphoribosyl pyrophosphate amidotransferase, an enzyme which is important in de novo purine synthesis.
Last Update: 2017-04-26
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prima etapă este catalizată de hipoxantin-guanin-fosforibozil transferază, producând tioinozina monofosfat (timp).
the first step is catalysed by hypoxanthine-guanine phosphoribosyl transferase yielding thioinosine monophosphate (timp).
Last Update: 2017-04-26
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de aceea, teoretic, trebuie evitată administrarea acestuia la pacienţii cu deficit ereditar rar de hipoxantin- guanin- fosforibozil - transferază (hgprt), cum ar fi cei cu sindromul lesch- nyhan şi cei cu sindromul kelley- seegmiller.
on theoretical grounds, therefore, it should be avoided in patients with rare hereditary deficiency of hypoxanthine-guanine phosphoribosyl-transferase (hgprt) such as lesch-nyhan and kelley-seegmiller syndrome.
Last Update: 2012-04-11
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