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v štandarných skúškach nevykazoval lepirudín mutagénne ani klastogénne účinky.
lepirudin was not mutagenic or clastogenic in standard assays for such effects.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
v predklinických štúdiách sa nepreukázali žiadne mutagénne ani klastogénne účinky.
no mutagenic or clastogenic effects were demonstrated in preclinical studies.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
v súvislosti s asa neboli zistené žiadne genotoxické ani klastogénne problémy.
no genotoxicity or clastogenicity issues of concern have been found with asa.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
efavirenz nevykazoval v klasických testoch genotoxicity ani mutagénne ani klastogénne vlastnosti.
efavirenz was not mutagenic or clastogenic in conventional genotoxicity assays.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
Štúdie genotoxického potenciálu anagrelidu nezistili žiadne mutagénne alebo klastogénne účinky.
studies on the genotoxic potential of anagrelide did not identify any mutagenic or clastogenic effects.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
napriek tomu, bivalirudín nepôsobil mutagénne ani klastogénne v štandardných testoch sledujúcich tieto účinky.
however, bivalirudin was not mutagenic or clastogenic in standard assays for such effects.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
mutagénny a karcinogénny potenciál Štúdie genotoxického potenciálu anagrelidu nezistili žiadne mutagénne alebo klastogénne účinky.
studies on the genotoxic potential of anagrelide did not identify any mutagenic or clastogenic effects.
Last Update: 2012-04-12
Usage Frequency: 2
Quality:
v testoch ames alebo testoch s ľudskými chromozomálnymi aberáciami sa klastogénne alebo mutagénne účinky natalizumabu nepozorovali.
no clastogenic or mutagenic effects of natalizumab were observed in the ames or human chromosomal aberration assays.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
deferiprón nepreukázal priame mutagénne vlastnosti, avšak mal klastogénne charakteristiky v in vitro skúškach a in vivo u zvierat.
deferiprone did not show direct mutagenic properties; however, it did display clastogenic characteristics in in vitro assays and in vivo in animals.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
mutagenita olanzapín nemal mutagénne ani klastogénne účinky v mnohých štandardných testoch vrátane testov bakteriálnych mutácií a in vitro a in vivo testov na cicavcoch.
97 mutagenicity olanzapine was not mutagenic or clastogenic in a full range of standard tests, which included bacterial mutation tests and in vitro and oral in vivo mammalian tests.
Last Update: 2012-04-12
Usage Frequency: 4
Quality:
mutagenita olanzapín nemal mutanogénne ani klastogénne účinky v žiadnom zo štandardných testov, vrátane testov bakteriálnych mutácií in vivo a in vitro testov na cicavcoch.
27 mutagenicity olanzapine was not mutagenic or clastogenic in a full range of standard tests, which included bacterial mutation tests and in vitro and in vivo mammalian tests.
Last Update: 2012-04-12
Usage Frequency: 4
Quality:
menej významný metabolit tfma (4-trifluórometylanilín) mal mutagénne a klastogénne účinky in vitro, ale nie in vivo.
the minor metabolite tfma (4-trifluoromethylaniline) caused mutagenicity and clastogenicity in vitro but not in vivo.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
ceftarolín fosamil a ceftarolín boli klastogénne v in vitro teste chromozómových aberácií, avšak v amesovom teste, teste myších lymfómov a teste neplánovanej syntézy dna sa mutagénna aktivita nedokázala.
ceftaroline fosamil and ceftaroline were clastogenic in an in vitro chromosomal aberration assay, however there was no evidence of mutagenic activity in an ames, mouse lymphoma and unscheduled dna synthesis assay.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
lapatinib nemal klastogénne alebo mutagénne účinky v súbore testov zahŕňajúcich test chromozómových aberácií v bunkách čínskeho škrečka, amesov test, test chromozómových aberácií v ľudských lymfocytoch a in vivo test chromozómových aberácií v bunkách kostnej drene potkanov.
lapatinib was not clastogenic or mutagenic in a battery of assays including the chinese hamster chromosome aberration assay, the ames assay, human lymphocyte chromosome aberration assay and an in vivo rat bone marrow chromosome aberration assay.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
Štúdie genotoxicity preukázali, že klofarabín nemal mutagénne účinky v analýze reverznej mutácie na baktériách, vyvolal však klastogénne účinky v teste chromozómových aberácií na bunkách vaječníkov čínskeho škrečka (cho) bez aktivácie a v teste potkanieho mikronukleusu in vivo.
genotoxicity studies demonstrated that clofarabine was not mutagenic in the bacterial reverse mutation assay, but did induce clastogenic effects in the non-activated chromosomal aberration assay in chinese hamster ovary (cho) cells and in the in vivo rat micronucleus assay.
Last Update: 2017-04-26
Usage Frequency: 3
Quality: