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el metabolito n-desmetilo continúa metabolizándose, con una vida media terminal de aproximadamente 4 horas.
the n-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h.
Last Update: 2017-04-26
Usage Frequency: 7
Quality:
según los resultados de estudios in vitro e in vivo, raltegravir se elimina principalmente metabolizándose por glucuronidación por la vía mediada por la ugt1a1.
based on in vitro and in vivo studies, raltegravir is eliminated mainly by metabolism via a ugt1a1- mediated glucuronidation pathway.
Last Update: 2017-04-26
Usage Frequency: 5
Quality:
no se han observado interacciones significativas cuando se administró sildenafilo (50 mg) concomitantemente con tolbutamida (250 mg) o warfarina (40 mg), metabolizándose ambos por el cyp2c9.
no significant interactions were shown when sildenafil (50 mg) was co-administered with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolised by cyp2c9.
Last Update: 2017-04-26
Usage Frequency: 7
Quality: