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autoinduktion leder också till motsvarande minskning av den
19 pharmacokinetics of autoinduction are characterised by an approximately 1.5 to 2 fold increase in the apparent oral clearance of nevirapine as treatment continues from a single dose to two-to-four weeks of dosing with 200-400 mg/ day.
Last Update: 2011-10-23
Usage Frequency: 1
Quality:
denna minskning beror sannolikt på autoinduktion av metaboliserande leverenzymer.
this decrease is probably due to auto-induction of metabolising liver enzymes.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
dessutom visar dessa resultat inga tecken på autoinduktion av anagrelids clearance.
additionally these results show no evidence of auto-induction of the anagrelide clearance.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
dessutom har autoinduktion av abakavirs metabolism eller induktion av andra läkemedels metabolism i levern inte observerats hos människa.
additionally, autoinduction of abacavir metabolism or induction of the metabolism of other medicinal products hepatically metabolised has not been observed in man.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
detta tyder på att rufinamids farmakokinetik är tidsoberoende (dvs. det sker ingen autoinduktion av metabolism).
when given twice daily at 12-hourly intervals, rufinamide accumulates to the extent predicted by its terminal half-life, indicating that the pharmacokinetics of rufinamide are time- independent (i. e. no autoinduction of metabolism).
Last Update: 2011-10-23
Usage Frequency: 1
Quality:
autoinduktion leder också till motsvarande minskning av den terminala plasmahalveringstiden av nevirapin från ca 45 timmar efter en engångsdos till ca 25-30 timmar efter upprepad dosering med 200-400 mg per dag.
autoinduction also results in a corresponding decrease in the terminal phase half-life of nevirapine in plasma from approximately 45 hours (single dose) to approximately 25-30 hours following multiple dosing with 200-400 mg/day.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
avsaknaden av effekt på farmakokinetiken av r - och s- warfarin samt avsaknaden av autoinduktion vid upprepade doser till patienter visar att cinacalcet inte inducerar cyp3a4, cyp1a2 eller cyp2c9 hos människa.
the lack of effect of cinacalcet on the pharmacokinetics of r- and s-warfarin and the absence of auto- induction upon multiple dosing in patients indicates that cinacalcet is not an inducer of cyp3a4, cyp1a2 or cyp2c9 in humans.
Last Update: 2012-04-11
Usage Frequency: 2
Quality:
upprepad tillförsel av bexaroten kan därför leda till en autoinduktion av dess egen metabolism och, i synnerhet vid dosnivåer över 300 mg/ m2/ dag, öka nedbrytningshastigheten och minska koncentrationerna i plasma av andra ämnen som metaboliseras av cytokrom p450 3a4, såsom tamoxifen.
therefore, repeated administration of bexarotene may result in an auto-induction of its own metabolism and, particularly at dose levels greater than 300 mg/ m2/ day, may increase the rate of metabolism and reduce plasma concentrations of other substances metabolised by cytochrome p450 3a4, such as tamoxifen.
Last Update: 2012-04-11
Usage Frequency: 2
Quality: