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/fosterutvecklingstoxicitet på cynomolgusapor för att vidareutforska de potentiella riskerna för fosterskador.
potential risk of foetal defects. the commission
Last Update: 2017-04-26
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46 toxicitetsstudier, inducerade pregabalin fosterutvecklingstoxicitet hos råttor vid exponeringar > 2 gånger den maximala, rekommenderade exponeringen hos människa.
in prenatal/postnatal toxicity studies, pregabalin induced offspring developmental toxicity in rats at exposures > 2 times the maximum recommended human exposure.
Last Update: 2012-04-11
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embryonal-fosterutvecklingstoxicitet hos råttor och kaniner har observerats efter administrering av tolkapon (se avsnitt 5.3).
in rats and rabbits, embryo-foetal toxicity was observed after tolcapone administration (see section 5.3).
Last Update: 2017-04-26
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i prenatala/postnatala toxicitetsstudier, inducerade pregabalin fosterutvecklingstoxicitet hos råttor vid exponeringar > 2 gånger den maximala, rekommenderade exponeringen hos människa.
in prenatal/postnatal toxicity studies, pregabalin induced offspring developmental toxicity in rats at exposures > 2 times the maximum recommended human exposure.
Last Update: 2017-04-26
Usage Frequency: 4
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vid studier av embryo-/fosterutvecklingstoxicitet på råttor och kaniner sågs utvecklingstoxicitet (ökad fosterförlust efter implantation, minskad kullstorlek och/eller sänkt fostervikt) vid doser om 500 respektive 150 mikrogram/kg/dag.
in embryo/foetal development toxicity studies in rats and rabbits, palifermin treatment was associated with developmental toxicity (increased post-implantation loss, reduced litter size, and/or reduced foetal weight) at doses of 500 and 150 micrograms/kg/day, respectively.
Last Update: 2017-04-26
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